Author

Hannah J. Lee

University of California, IrvineORCID 0000-0001-9098-2308Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alijah Macapagal· 1 shared Angela Lackner· 1 shared Hal M. HoffmaniD· 1 shared Huilin XuiD· 1 shared Janset OnyuruiD· 1 shared Julia Elise CabraliD· 1 shared Karen Wang· 1 shared Lauren Veronica AlbrechtiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Alijah Macapagal

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1 paper

Recent·Most cited

ImmunologyCommunications BiologyPeer-reviewedApr 16, 2026

TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950

Angela Lackner, Sofia I. Picucci, Wenjin Jiang…·Reginald McNulty

This paper shows that TH5487 and SU0268 inhibit NLRP3 activation in FCAS patient PBMCs, overcoming resistance to MCC950 by blocking inflammasome assembly and reducing IL-1β secretion.

2 citations

humanproteomics

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