Steven Jacobson

This study identifies RSAD2 and CMPK2 as key regulators of EBV reactivation and host interferon responses, revealing their coordinated immunometabolic role in viral latency and immune control.

ERVmancer is a phylogeny-informed method that resolves read-mapping ambiguity for HERVs, outperforming existing approaches and revealing new biology in breast cancer.

The paper identifies extracellular vesicles (sEVs) from EBV-transformed B-cells as a vehicle for exporting host DNA and EBV EBER1 RNA, linking peripheral EBV infection to distal tissue signaling in MS.

This study evaluates six potential serum biomarkers for multiple sclerosis in at-risk individuals and finds most are not robust predictors, though SPP1 shows a significant inverse correlation with genetic risk.

The paper develops RPSPASS, a software tool for automated analysis of microfluidic nanoparticle data, improving accuracy, ergonomics, and reporting transparency.

This study identifies chronic neuroinflammation in MS through scRNA-seq and proteomics, showing persistent IFN signaling and CD8 T cell cytotoxicity despite B-cell depletion.

This study shows HTLV-1 Tax induces mitophagy via PINK1-Parkin to suppress cGAS-STING activation and type I IFN, aiding viral persistence and cell survival.

The paper identifies spatiotemporal diversity of primate brain cells during white matter inflammatory demyelination using a cross-modality approach to inform lesion detection and management in multiple sclerosis.

The paper shows that loss of TDP-43 function leads to the expression of de novo proteins from mis-spliced mRNA transcripts in ALS/FTD.

The paper identifies thalamic commissures in primates, showing they connect cortex to contralateral thalamus and exist in both healthy and malformed human brains.

The paper shows TSPO expression increases in activated microglia in rodent models but not in human neurodegenerative diseases, indicating species-specific differences in TSPO function.

This study shows that in vivo MRI can detect remyelination in a nonhuman primate model of MS with high accuracy, suggesting its potential for preclinical and clinical applications.

The paper maps cell subclusters and their interactions in marmoset brain tissue, identifying WM-glia subtypes and their roles in neurological disorders.