Author

An-Jie Ler

Imperial College London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Christopher R. FullenkampiD· 1 shared Claudia Sanchez-CabanillasiD· 1 shared Dilek GuneriiD· 1 shared Ella Fan· 1 shared Enrico CadoniiD· 1 shared Gem FlintiD· 1 shared John S. SchneeklothiD· 1 shared Ling Sum LiuiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Christopher R. FullenkampORCID

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1 paper

Recent·Most cited

Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation.

Sabrina Pia Nuccio, Enrico Cadoni, Roxani Nikoloudaki, Silvia Galli, An-Jie Ler, Claudia Sanchez-Cabanillas, Thomas E. Maher, Ella Fan, Dilek Guneri, Gem Flint, Minghui Zhu, Ling Sum Liu, Christopher R. Fullenkamp, Zoë A. E. Waller, Luca Magnani, , Marco Di Antonio

This paper introduces ATENA, a method using chemically modified CRISPR-Cas9 to target specific G-quadruplexes and i-motifs, showing ligand-dependent transcriptional changes in c-MYC.

Nature Communications · Dec 9, 2025Peer-reviewedCell Biology