Cell BiologyNature CommunicationsPeer-reviewed
Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation.
Sabrina Pia Nuccio, Enrico Cadoni, Roxani Nikoloudaki…·Marco Di Antonio
This paper introduces ATENA, a method using chemically modified CRISPR-Cas9 to target specific G-quadruplexes and i-motifs, showing ligand-dependent transcriptional changes in c-MYC.
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