Sabrina Pia Nuccio

The paper shows that increased 4R Tau RNA contributes to motor neuron degeneration in ALS by reducing viability and that targeting this RNA could be therapeutic.

This paper designs and expresses non-natural membrane-less RNA organelles in E. coli, enabling algorithmic control over interactions and condensate structure.

This paper introduces ATENA, a method using chemically modified CRISPR-Cas9 to target specific G-quadruplexes and i-motifs, showing ligand-dependent transcriptional changes in c-MYC.

This paper introduces a platform for engineering synthetic RNA condensates that can form programmable organelles with controlled properties.

This paper introduces PRECISE, a method for programmable RNA editing that enables precise insertion, substitution, and deletion of RNA sequences in pre-mRNAs, with high efficiency and fidelity.