Author

André Richters

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Amaro N Taylor-WeineriD· 1 shared Amruth Kumar· 1 shared Angela N. KoehleriD· 1 shared Ann-Sophie Koglin· 1 shared Brendan Michael ReardoniD· 1 shared Charles A. WhittakeriD· 1 shared Christopher J. OttiD· 1 shared David LiuiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Amaro N Taylor-WeinerORCID

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2 papers

Recent·Most cited

Targeted Degradation of CDK9 Potently Disrupts the MYC Transcriptional Network

Mohammed A. Toure, Keisuke Motoyama, Yichen Xiang, Julie Urgiles, Florian Kabinger, Ann-Sophie Koglin, Ramya S. Iyer, Kaitlyn Gagnon, Amruth Kumar, Samuel Ojeda, Drew A. Harrison, Matthew G. Rees, Jennifer A. Roth, Christopher J. Ott, Richard P. Schiavoni, , Angela N. Koehler

This study shows that CDK9 degradation with KI-CDK9d-32 is more effective than inhibition in disrupting MYC transcriptional networks and causes MYC downregulation and nucleolar destabilization.

Cell chemical biology · Mar 29, 2025Peer-reviewedCancer Biology

Discovery of cancer driver genes based on nucleotide context

Felix Dietlein, Donate Weghorn, Amaro N Taylor-Weiner, André Richters, Brendan Michael Reardon, David Liu, Eric S. Lander, Eliezer M. Van Allen, Shamil R. Sunyaev

This study identifies novel cancer driver genes by analyzing mutation nucleotide contexts in whole-exome sequencing data from 12,004 tumors.

Nature Genetics · Feb 1, 2020Peer-reviewedGenetics