Author

Mohammed A. Toure

Broad InstituteORCID 0000-0002-2472-0729Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 1

Frequent Co-Authors

Angela N. KoehleriD· 2 shared Yichen XiangiD· 2 shared Alexandra N. WuestiD· 1 shared Alinur Jaboldinov· 1 shared Amruth Kumar· 1 shared André Richters· 1 shared Ann-Sophie Koglin· 1 shared Charles A. WhittakeriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Angela N. KoehlerORCID

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2 papers

Recent·Most cited

A functional map of CDK-drug interactions at single amino acid resolution

Samuel I. Gould, Jonuelle Acosta, Luca Boscolo Bielo, Alinur Jaboldinov, Grace A. Johnson, Manuel E. Contreras, Alexandra N. Wuest, Emmanuel Brémont, Mohammed A. Toure, Yichen Xiang, Zuzanna Kozicka, Michael T. Hemann, Angela N. Koehler, Sarat Chandarlapaty, Francisco J. Sánchez Rivera

The paper maps CDK-drug interactions at single amino acid resolution using genome editing and computational analysis, identifying critical residues and resistance mechanisms.

bioRxiv · Nov 2, 2025 · PreprintCancer Biology

Targeted Degradation of CDK9 Potently Disrupts the MYC Transcriptional Network

Mohammed A. Toure, Keisuke Motoyama, Yichen Xiang, Julie Urgiles, Florian Kabinger, Ann-Sophie Koglin, Ramya S. Iyer, Kaitlyn Gagnon, Amruth Kumar, Samuel Ojeda, Drew A. Harrison, Matthew G. Rees, Jennifer A. Roth, Christopher J. Ott, Richard P. Schiavoni, , Angela N. Koehler

This study shows that CDK9 degradation with KI-CDK9d-32 is more effective than inhibition in disrupting MYC transcriptional networks and causes MYC downregulation and nucleolar destabilization.

Cell chemical biology · Mar 29, 2025Peer-reviewedCancer Biology