Author

Keisuke Motoyama

Broad InstituteORCID 0000-0002-4273-960XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

Angela N. KoehleriD· 2 shared Yichen XiangiD· 2 shared Amruth Kumar· 1 shared André Richters· 1 shared Ann-Sophie Koglin· 1 shared Arianna Arroyo-Ortega· 1 shared Charles A. WhittakeriD· 1 shared Chi-Chao CheniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Angela N. KoehlerORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Epigenetic Reactivation of Lineage Differentiation to Target Leukemia

Shandon M Amos, Chi-Chao Chen, Yichen Xiang, Keisuke Motoyama, Tania J González-Robles, Varun K. Narendra, Grace A. Johnson, Han‐Teo Lee, Yu-Jui Ho, Ipek Celikoyar, Ziyang Ye, Shenghao Guo, Claire Glickman, Natalie A. O’Hearn, Oindrila Sarkar, , Yadira M. Soto‐Feliciano

This study identifies TRIM28 as a critical regulator in acute leukemia, showing its depletion promotes neutrophil differentiation and reduces leukemic potential, with a small-molecule inhibitor developed to target it.

bioRxiv · Jul 10, 2026 · PreprintCancer Biology

Targeted Degradation of CDK9 Potently Disrupts the MYC Transcriptional Network

Mohammed A. Toure, Keisuke Motoyama, Yichen Xiang, Julie Urgiles, Florian Kabinger, Ann-Sophie Koglin, Ramya S. Iyer, Kaitlyn Gagnon, Amruth Kumar, Samuel Ojeda, Drew A. Harrison, Matthew G. Rees, Jennifer A. Roth, Christopher J. Ott, Richard P. Schiavoni, , Angela N. Koehler

This study shows that CDK9 degradation with KI-CDK9d-32 is more effective than inhibition in disrupting MYC transcriptional networks and causes MYC downregulation and nucleolar destabilization.

Cell chemical biology · Mar 29, 2025Peer-reviewedCancer Biology