Deep learning-driven neuromorphogenesis screenings identify repurposable drugs for mitochondrial disease
Carmen Menacho, Satoshi Okawa, Iris Álvarez‐Merz, Annika Wittich, Mikel Muñoz‐Oreja, Paweł Lisowski, Tancredi Massimo Pentimalli, Agnieszka Rybak‐Wolf, Gizem Inak, Shiri Zakin, Mathuravani A. Thevandavakkam, Laura Petersilie, Andrea Zaliani, Barbara Mlody, Annette Seibt, , Alessandro Prigione
The paper identifies repurposable drugs for mitochondrial disease by using deep learning to screen for compounds that improve neuronal commitment and neurogenesis in Leigh syndrome organoids.
bioRxiv · Jul 8, 2024 · PreprintNeuroscience