Carmen Menacho

Glucocorticoid receptors mediate reprogramming of astrocytes in depression.

The paper identifies glucocorticoid receptor-mediated astrocyte reprogramming in depression using post-mortem samples and mouse models.

Mutant Huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure

This study shows that mutant Huntingtin causes neurodevelopmental issues in human brain organoids by disrupting CHCHD2, leading to mitochondrial and metabolic problems.

Deep learning-driven neuromorphogenesis screenings identify repurposable drugs for mitochondrial disease

The paper identifies repurposable drugs for mitochondrial disease by using deep learning to screen for compounds that improve neuronal commitment and neurogenesis in Leigh syndrome organoids.

Defective neuritogenesis in Abcd1/2 deficient rat neurons due to intrinsic and astrocyte-dependent mechanisms

This study identifies neurodevelopmental defects in X-ALD using rat models, showing intrinsic and astrocyte-dependent mechanisms affecting neuritogenesis.

Flexible, fast and selective genetic manipulation of the vertebrate CNS with misPiggy

The paper introduces a transposon-based system for genetic manipulation of the vertebrate CNS, enabling long-term conditional experiments across cell types and species.