Regulation of proteasome activation by a ubiquitin-independent feedback mechanism
Samuel J. Watson, James C. Williamson, Pehuén Pereyra Gerber, Guinevere L. Grice, Claudia Melucci, Aneisha Duggal, Christian M. Gawden‐Bone, Niek Wit, Richard T. Timms, James A. Nathan, Nicholas J. Matheson, Paul J. Lehner
This study identifies ZFAND5/6 as ubiquitin-independent proteasome activators that regulate NF-κB signaling by degrading UBCH5c.
bioRxiv · Jun 9, 2026 · PreprintBiochemistry