Paul J. Lehner

This study assesses cross-neutralisation of sarbecoviruses by COVID-19 vaccines in older adults, finding reduced neutralisation of Omicron variants and some animal sarbecoviruses but enhanced neutralisation of specific bat and pangolin coronaviruses.

This study identifies ZFAND5/6 as ubiquitin-independent proteasome activators that regulate NF-κB signaling by degrading UBCH5c.

This paper identifies gpUL141 as a HCMV virion component that modulates envelope glycoprotein trafficking to evade humoral immunity.

This study generates HLA-edited cholangiocyte organoids with reduced immunogenicity and reports their mutation profiles and immune response in vitro and in vivo.

This paper identifies the HUSH-SETDB1-MORC2 complex as essential for maintaining HSV-1 latency by promoting H3K9me3 chromatin marks on viral genomes in neurons.

This study identifies Periphilin as the RNA-binding component of the HUSH complex and shows that RNA-binding is essential for HUSH function.

The paper shows that altered sulfatide-binding by NF155 links glycosphingolipid imbalances to demyelination by affecting membrane protein abundance and axon-myelin contacts.

The paper identifies TASOR as a pseudo-PARP essential for HUSH complex assembly and epigenetic repression of transposons.

This study shows neural stem cells transfer functional mitochondria via extracellular vesicles to restore mitochondrial function in target cells, improving disease outcomes in multiple sclerosis.