Floris P. J. van Alphen

The paper analyzes transcriptome and proteome data of human naive and memory B cells to identify isotype-specific phenotypes, finding distinct expression profiles in IgG4-switched B cells.

The paper maps dynamic RNA-binding proteins in human effector T cells and identifies TUT1 and SF3A1 as regulators of differentiation and cytotoxicity.

This study identifies a novel mTOR-dependent mechanism regulating cytokine production in T cells through 3UTR AU-rich elements and DDX21 binding.

The paper maps the ZFP36L1 interactome in human T cells using proximity labeling, revealing its role in post-transcriptional regulation and protein expression.

This study shows that SPPL3 in tumor cells affects innate immune responses by modulating nsGSLs, reducing susceptibility to neutrophils, NK cells, and γδ T cells.

This study identifies Csde1-bound transcripts in erythropoiesis and shows that Csde1 regulates their expression through effects on mRNA stability and translation.

This study identifies Strap as a key partner of Csde1 in erythroblasts, showing that their complex regulates the translation of transcripts critical for erythropoiesis and hypoxia response.