Chun‐Kan Chen

Synthetic circRNAs employ IRES activity for translation in cells and in cell-free translation systems

The paper examines the translation efficiency of synthetic circRNAs using different IRESes in human cells and in vitro systems, finding that several IRESes effectively drive circRNA translation.

YTHDC1 cooperates with the THO complex to prevent RNA damage-induced DNA breaks

This study shows that RNA damage can cause DNA breaks through R-loop formation, and YTHDC1-THOC prevents this by binding to m1A-modified RNAs.

An Xist-dependent protein assembly mediates Xist localization and gene silencing

The paper shows that Xist RNA forms a protein condensate with binding proteins to establish the Xi-compartment and maintain gene silencing.