Author

Tsotne Chitiashvili

Calico Life SciencesORCID 0000-0002-4887-1097Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Aaron W. StebbinsiD· 1 shared Agnieszka A. WendorffiD· 1 shared Alexander L. LiiD· 1 shared Amy Pandya‐JonesiD· 1 shared Andrey DamianoviD· 1 shared Andy J. ChangiD· 1 shared Anthony C. Chau· 1 shared Astrid GillichiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

Aaron W. StebbinsORCID

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2 papers

Recent·Most cited

Wnt signaling decline drives age-related alveolar stem cell loss and impairs lung repair

Tsotne Chitiashvili, Alexander L. Li, Agnieszka A. Wendorff, K. Sivasubramanian, Wenjun Kong, Erik Arroyo-Colon, Ziyou Ren, Evangelia Malahias, Po-Han Tai, Georgina Duenas, John C. K. Wang, Kexin Kong, Ngoc Vu, John M. Patino, Wendy Craft, , Astrid Gillich

This study identifies declining Wnt signaling as a driver of age-related alveolar stem cell loss and shows that restoring Wnt signaling in aged mice improves lung repair but not full regeneration.

bioRxiv · Aug 21, 2026 · PreprintCell Biology

An Xist-dependent protein assembly mediates Xist localization and gene silencing

Amy Pandya‐Jones, Yolanda Markaki, Jacques Serizay, Tsotne Chitiashvili, Walter Mancia, Andrey Damianov, Constantinos Chronis, Bernadett Papp, Chun‐Kan Chen, Robin McKee, Xiaojun Wang, Anthony C. Chau, Shan Sabri, Heinrich Leonhardt, Sika Zheng, , Kathrin Plath

The paper shows that Xist RNA forms a protein condensate with binding proteins to establish the Xi-compartment and maintain gene silencing.

Nature · Sep 9, 2020Peer-reviewedMolecular Biology