Proteome-Wide Discovery of Degradable Proteins Using Bifunctional Molecules
Ines Forrest, Louis Patrick Conway, Clara Gathmann, Appaso Mahadev Jadhav, Tzu-Yuan Chiu, Christian M. Chaheine, Michelle A. Estrada, Anurupa Shrestha, Kathy Sarris, Justin M. Reitsma, Scott E. Warder, Anil Vasudevan, Shaun M. McLoughlin, Christopher G. Parker
The paper introduces AgnoTACs, bifunctional molecules that enable proteome-wide discovery of degradable proteins, identifying over 50 previously untargeted proteins.
ACS Central Science · Oct 21, 2025Peer-reviewedBiochemistry