Shaun M. McLoughlin

This study uses native mass spectrometry to show how PROTAC linker length and targeting ligand affect ternary complex structure and stability.

The paper introduces AgnoTACs, bifunctional molecules that enable proteome-wide discovery of degradable proteins, identifying over 50 previously untargeted proteins.

This paper demonstrates a high-throughput phenotypic screening method using IR-MALDESI mass spectrometry to identify glutaminase inhibitors and distinguish them from nuisance compounds.