Kyong Tkhe Fam

NOD2 restrains probiotic-mediated TLR2-dependent antitumor immunity

This study shows that NOD2 inhibits TLR2-dependent antitumor immunity induced by Lactiplantibacillus plantarum, highlighting its role as a checkpoint in microbial sensing.

Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium

This study shows that inhibiting SagA, a peptidoglycan hydrolase, increases vancomycin susceptibility in VREfm through both genetic and pharmacological approaches.

T-bet Expressing B cells are Key Determinants of Protective Immunity Against Norovirus Infection

This study identifies T-bet expressing B cells as critical for mucosal immunity and protection against norovirus infection through IgG and IgA responses.

Allele-Specific Effects of Mutations in the Rifampin Resistance-Determining Region (RRDR) of RpoB on Physiology and Antibiotic Resistance in Enterococcus faecium

This study examines allele-specific effects of Rifampin Resistance-Determining Region (RRDR) mutations in RpoB on E. faecium physiology and antibiotic resistance, revealing varied impacts on growth, susceptibility, and hospital survival.

Microbiota-derived secondary bile acids promote STING activation and antitumor activity

This study identifies DCA as a microbiota-derived bile acid that activates STING and enhances antitumor immunity via NK cell activation.

Photoactivatable Plasma Membrane Probe Through Self-Triggered Photooxidation Cascade for Live Super-Resolution Microscopy

Molecular Tuning of Styryl Dyes Leads to Versatile and Efficient Plasma Membrane Probes for Cell and Tissue Imaging

This paper develops new styryl dyes with improved photophysical properties for plasma membrane imaging in mammalian and plant cells.