Cell-of-origin shapes tumor subtype in BRCA1-associated triple-negative breast cancer
Tatyana Lev, Angela Lincy Prem Antony Samy, Sharmila Mallya, Isam Adam, Dana Pueschl, Dennis Ma, Timothy P McMullen, Mandeep S. Lev, Jessica G Gonzalez, Aaron J. Longworth, Arjun Nair, Xin Lu, Andrew K. Godwin, Paul Andrew James, Phuong L. Mai, , Devon A. Lawson
This study identifies two cell-of-origin-driven subtypes of BRCA1-associated TNBC, showing that tumor subtype depends on the cell type initiating the cancer.
bioRxiv · Sep 30, 2026 · PreprintCancer Biology