B. A. Jones

Estrogen-related receptor agonism reverses mitochondrial dysfunction and inflammation in the aging kidney

This study shows that ERR agonism improves mitochondrial function and reduces inflammation in aging kidneys, while STING inhibition also reduces inflammation and increases mitochondrial gene expression.

Farnesoid X receptor agonism prevents neutrophil extracellular traps via reduced sphingosine-1-phosphate in chronic kidney disease

This study shows FXR agonism reduces kidney NETosis in male mice by inhibiting S1P signaling, but not in females.

Comparative efficacy of antiviral strategies targeting different stages of the viral life cycle: A viral quasispecies dynamics study

This study compares antiviral strategies targeting different stages of the viral life cycle using a quasispecies dynamics model, finding varying impacts on viral load and effectiveness in low-immunity individuals.

PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy

This study shows that PKR inhibition reduces mitochondrial dysfunction and ameliorates HIV-associated nephropathy in transgenic mice using single-nucleus and bulk RNA-seq.

Modeling the dynamics of within-host viral infection and evolution predicts quasispecies distributions and phase boundaries separating distinct classes of infections

The paper models within-host viral infection dynamics to predict quasispecies distributions and phase boundaries distinguishing acute, chronic, and opportunistic infections.

NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease

This study shows that nicotinamide riboside (NR) improves mitochondrial function and reduces inflammation in diabetic kidney disease by enhancing NAD metabolism and inhibiting the cGAS-STING pathway.

A user-friendly tool for cloud-based whole slide image segmentation, with examples from renal histopathology

Histo-Cloud is a cloud-based tool for whole slide image segmentation that simplifies access for non-experts, demonstrating its use in renal histopathology.

PodoCount: A robust, fully automated whole-slide podocyte quantification tool

PodoCount quantifies podocytes in kidney tissues with high accuracy, showing strong correlation with disease diagnosis and clinical outcomes in both murine models and human diabetic nephropathy.

Beyond taxonomic identification: integration of ecological responses to a soil bacterial 16S rRNA gene database.

The paper creates a soil-specific 16S rRNA gene database with ecological traits and demonstrates its utility in predicting pH responses of soil bacterial taxa.