Author

J. B. Kopp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 7 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell type annotation· 7 Organism:mouse· 7 Research Focus:differential expression· 5 Organism:human· 4 Assay:imaging· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

A. Z. Rosenberg· 9 shared M. Levi· 6 shared T. Yoshida· 6 shared B. A. Jones· 5 shared K. Myakala· 5 shared P. Sarder· 5 shared C. A. Winkler· 4 shared K. Z. Latt· 4 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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9 shared papersPathology

A. Z. Rosenberg

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Estrogen-related receptor agonism reverses mitochondrial dysfunction and inflammation in the aging kidney

X. X. Wang, K. Myakala, A. E. Libby, S. Ranjit, S. Takahashi, B. A. Jones, K. Bhasin, Y. Qi, K. Krausz, P. Zerfas, J. Panov, t. J. velenosi, d. P. patel, P. Daneshpajouhnejad, A. Titievsky, , M. Levi

This study shows that ERR agonism improves mitochondrial function and reduces inflammation in aging kidneys, while STING inhibition also reduces inflammation and increases mitochondrial gene expression.

The American Journal of Pathology · Dec 1, 2023Peer-reviewedPathology

APOL1 kidney risk variants in glomerular diseases modeled in transgenic mice

T. Yoshida, K. Z. Latt, B. A. Santo, S. Shrivastav, Y. Zhao, P. Fenaroli, J.-Y. Chung, S. M. Hewitt, V. M. Tutino, P. Sarder, A. Z. Rosenberg, C. A. Winkler, J. B. Kopp

This paper uses two transgenic mouse models to study APOL1 risk variants' effects on glomerular disease, identifying shared and distinct transcriptional changes in podocytes.

bioRxiv · Mar 27, 2023Pathology

HIV viral protein R induces loss of DCT1-type renal tubules

K. Z. Latt, T. Yoshida, S. Shrivastav, A. Abedini, J. M. Reece, Z. Sun, H. Lee, K. Okamoto, P. Dagur, J. Heymann, Y. Zhao, J.-Y. Chung, S. Hewitt, P. A. Jose, K. Lee, , J. B. Kopp

This study shows HIV Vpr reduces DCT1-type renal tubules in mice, leading to salt wasting via apoptosis dysregulation of Slc12a3+ Pvalb+ cells.

bioRxiv · Feb 2, 2023 · PreprintPathology

PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy

T. Yoshida, K. Z. Latt, A. Z. Rosenberg, B. A. Santo, K. Myakala, Y. Ishimoto, Y. Zhao, S. Shrivastav, B. A. Jones, X. Yang, X. Wang, V. M. Tutino, P. Sarder, M. Levi, K. Okamoto, , J. B. Kopp

This study shows that PKR inhibition reduces mitochondrial dysfunction and ameliorates HIV-associated nephropathy in transgenic mice using single-nucleus and bulk RNA-seq.

bioRxiv · Oct 3, 2022Pathology

NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease

K. Myakala, X. Wang, N. V. Shults, B. A. Jones, X. Yang, A. Z. Rosenberg, B. Ginley, P. Sarder, L. Brodsky, Y. Jang, C. H. Na, Y. Chi, X. Zhang, U. Guha, C. Wu, , M. Levi

This study shows that nicotinamide riboside (NR) improves mitochondrial function and reduces inflammation in diabetic kidney disease by enhancing NAD metabolism and inhibiting the cGAS-STING pathway.

bioRxiv · Dec 5, 2021Pathology

A user-friendly tool for cloud-based whole slide image segmentation, with examples from renal histopathology

B. R. Lutnick, D. Manthey, J. U. Becker, B. Ginley, K. Moos, J. E. Zuckerman, L. Rodrigues, A. J. Gallan, L. Barisoni, C. E. Alpers, X. Wang, K. Myakala, B. A. Jones, M. Levi, J. B. Kopp, , Kidney Precision Medicine Project

Histo-Cloud is a cloud-based tool for whole slide image segmentation that simplifies access for non-experts, demonstrating its use in renal histopathology.

bioRxiv · Aug 16, 2021Pathology

PodoCount: A robust, fully automated whole-slide podocyte quantification tool

B. A. Santo, D. Govind, P. Daneshpajouhnejad, X. Yang, X. X. Wang, K. Myakala, B. A. Jones, M. Levi, J. B. Kopp, L. J. Niedernhofer, D. Manthey, K. C. Moon, S. S. Han, A. Z. Rosenberg, P. Sarder

PodoCount quantifies podocytes in kidney tissues with high accuracy, showing strong correlation with disease diagnosis and clinical outcomes in both murine models and human diabetic nephropathy.

bioRxiv · Apr 27, 2021Pathology

TAZ/TEAD complex regulates TGF-β1-mediated fibrosis in iPSC-derived renal organoids

X. Yang, M. Delsante, P. Deneshpajouhnejad, P. Fenaroli, K. P. Mandell, X. Wang, S. Takahashi, M. K. Halushka, J. B. Kopp, M. Levi, A. Z. Rosenberg

This study shows that INT-767 prevents fibrosis in iPSC-derived renal organoids by modulating the TEAD4/TAZ pathway.

bioRxiv · Apr 15, 2021 · PreprintCell Biology

Urine single cell RNA-sequencing in focal segmental glomerulosclerosis reveals inflammatory signatures in immune cells and podocytes

K. Z. Latt, J. Heymann, J. H. Jessee, A. Z. Rosenberg, C. C. Berthier, S. Eddy, T. Yoshida, Y. Zhao, V. Chen, G. W. Nelson, M. Cam, P. Kumar, M. Mehta, M. C. Kelly, M. Kretzler, , J. B. Kopp

This study uses urine single cell RNA-sequencing to identify inflammatory signatures in immune cells and podocytes in FSGS, suggesting potential for non-invasive diagnosis and biomarker discovery.

bioRxiv · Oct 18, 2020Immunology