W. F. Marshall

Reduced Telomerase Interaction with Telomeres Alters Meiotic Chromosome Motion and Gamete Viability

This study shows that reduced telomerase interaction with telomeres in yeast affects meiotic chromosome motion and gamete viability by altering recombination and cytoskeletal forces.

Homologous chromosome recognition via nonspecific interactions

The paper proposes a 'button barcode' model for homologous chromosome recognition, showing that non-specific interactions with non-uniformly distributed sites can achieve high pairing fidelity.

Role of intraflagellar transport in transcriptional control during flagellar regeneration in Chlamydomonas

The paper models how transcriptional repression is controlled during flagellar regeneration in Chlamydomonas, showing that IFT mutants reduce gene expression, supporting a repressor sequestration model.

Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular ciliate Stentor

This study shows that hydrodynamic coupling in Stentor colonies enhances feeding efficiency, with asymmetric benefits depending on individual solitary feeding rates.

Genome-wide analysis of anterior-posterior mRNA regionalization in Stentor coeruleus reveals a role for the microtubule cytoskeleton

The paper identifies anterior-posterior mRNA regionalization in Stentor coeruleus and shows microtubules are involved in maintaining this distribution through RNAi experiments.

Proteomic analysis of flagella from Chlamydomonas mutants lacking the central pair apparatus reveals loss of radial spoke head proteins

The paper identifies proteins depleted from flagella of Chlamydomonas mutants lacking the central pair apparatus, revealing roles for radial spoke head proteins and MIPs in axonemal structure.

Testing the ion-current model for flagellar length sensing and IFT regulation

This study tests the ion-current model for flagellar length sensing by measuring Ca2+ levels and IFT injection in Chlamydomonas, finding no support for the model's predictions.

Modeling Cell Biological Features of Meiotic Chromosome Pairing

This paper uses a computational model to study how meiotic chromosome pairing occurs, finding that distributed pairing sites and telomere motion enhance pairing while interlocks resolve through telomere proximity and cooperativity.

Proteomic Dissection of a Giant Cell

The paper quantifies polarized protein localization in Stentor coeruleus by cutting cells along the anterior-posterior axis and analyzing proteomic enrichment, finding 30% of proteins show polarized localization.

Modeling the dynamics of within-host viral infection and evolution predicts quasispecies distributions and phase boundaries separating distinct classes of infections

The paper models within-host viral infection dynamics to predict quasispecies distributions and phase boundaries distinguishing acute, chronic, and opportunistic infections.

The short flagella 1 (SHF1) gene in Chlamydomonas encodes a Crescerin TOG-domain protein required for late stages of flagellar growth.

The paper identifies SHF1 as a Crescerin TOG-domain protein in Chlamydomonas required for flagellar growth, showing it enhances tubulin polymerization and compensates for decreasing IFT cargo.

The nuclear transport factor CSE1 drives macronuclear volume increase and macronuclear node coalescence in Stentor coeruleus

Modular, Cascade-like Transcriptional Program of Regeneration in Stentor

This study uses RNAseq to analyze transcriptional changes during regeneration in Stentor coeruleus, identifying distinct gene expression modules and a cascade mechanism involving translation products of early-expressed genes.

A unicellular walker controlled by a microtubule-based finite state machine

The paper demonstrates finite state machine-like processing in the walking behavior of Euplotes eurystomus by analyzing gait state transitions and their association with microtubule dynamics.

Microfluidic guillotine reveals multiple timescales and mechanical modes of wound response in Stentor coeruleus

This study uses a microfluidic guillotine to analyze wound repair in Stentor coeruleus, revealing three mechanical modes and faster healing rates than previously reported.

Analysis of Biological Noise in an Organelle Size Control System

The paper analyzes biological noise in flagellar length control in Chlamydomonas, showing cell-to-cell and within-cell variation and linking it to homeostatic mechanisms and tubulin dynamics.

Speed and diffusion of kinesin-2 are competing limiting factors in flagellar length control model

The paper models how kinesin-2 motor speed and diffusion coefficient influence flagellar length in Chlamydomonas, showing two distinct regulatory regimes based on length and mutation effects.

Reorganisation of complex ciliary flows around regenerating Stentor coeruleus

This study investigates ciliary restructuring and hydrodynamics during oral regeneration in Stentor coeruleus induced by sucrose-shock.

Dynamics of living cells in a cytomorphological state space

The paper applies equilibrium dynamics formalisms to describe cellular transition dynamics in a cytomorphological state space of mouse embryonic fibroblasts, revealing non-uniform energy landscapes and their response to apoptotic agents.

Modeling meiotic chromosome pairing: increased fidelity from a tug of war between telomere forces and a pairing-based Brownian ratchet

The paper models meiotic chromosome pairing, showing that telomere forces and a pairing-based Brownian ratchet mechanism enhance pairing fidelity by amplifying affinity differences between homologous and homeologous regions.

Inferring cell state by quantitative motility analysis reveals a dynamic state system and broken detailed balance

The paper develops Heteromotility to analyze cell motility and identifies dynamic motility states in mouse cells, finding broken detailed balance in muscle stem cells.

Diffusion as a ruler: modeling kinesin diffusion as a length sensor for intraflagellar transport

The paper models kinesin diffusion as a mechanism for measuring flagellar length during intraflagellar transport, showing it can achieve stable length regulation without additional signaling.