Author

K. Myakala

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 5 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 7 Research Focus:cell type annotation· 4 Assay:imaging· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2

Frequent Co-Authors

M. Levi· 7 shared A. Z. Rosenberg· 6 shared B. A. Jones· 6 shared J. B. Kopp· 5 shared P. Sarder· 5 shared X. Wang· 4 shared X. Yang· 4 shared B. Ginley· 3 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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7 shared papersPathology

M. Levi

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Estrogen-related receptor agonism reverses mitochondrial dysfunction and inflammation in the aging kidney

X. X. Wang, K. Myakala, A. E. Libby, S. Ranjit, S. Takahashi, B. A. Jones, K. Bhasin, Y. Qi, K. Krausz, P. Zerfas, J. Panov, t. J. velenosi, d. P. patel, P. Daneshpajouhnejad, A. Titievsky, , M. Levi

This study shows that ERR agonism improves mitochondrial function and reduces inflammation in aging kidneys, while STING inhibition also reduces inflammation and increases mitochondrial gene expression.

The American Journal of Pathology · Dec 1, 2023Peer-reviewedPathology

Farnesoid X receptor agonism prevents neutrophil extracellular traps via reduced sphingosine-1-phosphate in chronic kidney disease

B. A. Jones, K. Myakala, M. Guha, S. Davidson, S. Adapa, I. Lopez Santiago, I. Schaffer, Y. Yue, J. Allegood, L. A. Cowart, X. X. Wang, A. Z. Rosenberg, M. Levi

This study shows FXR agonism reduces kidney NETosis in male mice by inhibiting S1P signaling, but not in females.

bioRxiv · Mar 1, 2023Pharmacology & Toxicology

PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy

T. Yoshida, K. Z. Latt, A. Z. Rosenberg, B. A. Santo, K. Myakala, Y. Ishimoto, Y. Zhao, S. Shrivastav, B. A. Jones, X. Yang, X. Wang, V. M. Tutino, P. Sarder, M. Levi, K. Okamoto, , J. B. Kopp

This study shows that PKR inhibition reduces mitochondrial dysfunction and ameliorates HIV-associated nephropathy in transgenic mice using single-nucleus and bulk RNA-seq.

bioRxiv · Oct 3, 2022Pathology

NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease

K. Myakala, X. Wang, N. V. Shults, B. A. Jones, X. Yang, A. Z. Rosenberg, B. Ginley, P. Sarder, L. Brodsky, Y. Jang, C. H. Na, Y. Chi, X. Zhang, U. Guha, C. Wu, , M. Levi

This study shows that nicotinamide riboside (NR) improves mitochondrial function and reduces inflammation in diabetic kidney disease by enhancing NAD metabolism and inhibiting the cGAS-STING pathway.

bioRxiv · Dec 5, 2021Pathology

Endothelial Cell-Specific Molecule-1 Inhibits Albuminuria in Diabetic Mice

X. Zheng, L. Higdon, A. Gaudet, M. Shah, A. Balistieri, C. Li, P. Nadai, L. Palaniappan, X. Yang, B. Santo, B. Ginley, X. Wang, K. Myakala, P. Nallagatla, M. Levi, , V. Bhalla

This study shows that Esm-1 reduces albuminuria and podocyte injury in diabetic mice, possibly through inhibiting interferon signaling.

bioRxiv · Oct 14, 2021Immunology

A user-friendly tool for cloud-based whole slide image segmentation, with examples from renal histopathology

B. R. Lutnick, D. Manthey, J. U. Becker, B. Ginley, K. Moos, J. E. Zuckerman, L. Rodrigues, A. J. Gallan, L. Barisoni, C. E. Alpers, X. Wang, K. Myakala, B. A. Jones, M. Levi, J. B. Kopp, , Kidney Precision Medicine Project

Histo-Cloud is a cloud-based tool for whole slide image segmentation that simplifies access for non-experts, demonstrating its use in renal histopathology.

bioRxiv · Aug 16, 2021Pathology

PodoCount: A robust, fully automated whole-slide podocyte quantification tool

B. A. Santo, D. Govind, P. Daneshpajouhnejad, X. Yang, X. X. Wang, K. Myakala, B. A. Jones, M. Levi, J. B. Kopp, L. J. Niedernhofer, D. Manthey, K. C. Moon, S. S. Han, A. Z. Rosenberg, P. Sarder

PodoCount quantifies podocytes in kidney tissues with high accuracy, showing strong correlation with disease diagnosis and clinical outcomes in both murine models and human diabetic nephropathy.

bioRxiv · Apr 27, 2021Pathology