A. Z. Rosenberg

ComPRePS: Unlocking Scalable AI Analysis for Computational Renal Pathology

ComPRePS improves renal pathology analysis by automating WSI processing and AI-assisted interpretation, enhancing precision and interobserver agreement in key lesion assessments.

Estrogen-related receptor agonism reverses mitochondrial dysfunction and inflammation in the aging kidney

This study shows that ERR agonism improves mitochondrial function and reduces inflammation in aging kidneys, while STING inhibition also reduces inflammation and increases mitochondrial gene expression.

APOL1 kidney risk variants in glomerular diseases modeled in transgenic mice

This paper uses two transgenic mouse models to study APOL1 risk variants' effects on glomerular disease, identifying shared and distinct transcriptional changes in podocytes.

Farnesoid X receptor agonism prevents neutrophil extracellular traps via reduced sphingosine-1-phosphate in chronic kidney disease

This study shows FXR agonism reduces kidney NETosis in male mice by inhibiting S1P signaling, but not in females.

HIV viral protein R induces loss of DCT1-type renal tubules

This study shows HIV Vpr reduces DCT1-type renal tubules in mice, leading to salt wasting via apoptosis dysregulation of Slc12a3+ Pvalb+ cells.

PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy

This study shows that PKR inhibition reduces mitochondrial dysfunction and ameliorates HIV-associated nephropathy in transgenic mice using single-nucleus and bulk RNA-seq.

The SARS-CoV-2 spike protein binds and modulates estrogen receptors

This study identifies a novel interaction between SARS-CoV-2 spike protein and estrogen receptor alpha, showing its role in modulating ER activity and ACE2 expression in infected cells and tissues.

NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease

This study shows that nicotinamide riboside (NR) improves mitochondrial function and reduces inflammation in diabetic kidney disease by enhancing NAD metabolism and inhibiting the cGAS-STING pathway.

A user-friendly tool for cloud-based whole slide image segmentation, with examples from renal histopathology

Histo-Cloud is a cloud-based tool for whole slide image segmentation that simplifies access for non-experts, demonstrating its use in renal histopathology.

PodoCount: A robust, fully automated whole-slide podocyte quantification tool

PodoCount quantifies podocytes in kidney tissues with high accuracy, showing strong correlation with disease diagnosis and clinical outcomes in both murine models and human diabetic nephropathy.

TAZ/TEAD complex regulates TGF-β1-mediated fibrosis in iPSC-derived renal organoids

This study shows that INT-767 prevents fibrosis in iPSC-derived renal organoids by modulating the TEAD4/TAZ pathway.

Neutralizing IFNL3 Autoantibodies in Severe COVID-19 Identified Using Molecular Indexing of Proteins by Self-Assembly

MIPSA identifies neutralizing IFNL3 autoantibodies in severe COVID-19 patients by profiling autoantibodies against DNA-barcoded proteins.

Urine single cell RNA-sequencing in focal segmental glomerulosclerosis reveals inflammatory signatures in immune cells and podocytes

This study uses urine single cell RNA-sequencing to identify inflammatory signatures in immune cells and podocytes in FSGS, suggesting potential for non-invasive diagnosis and biomarker discovery.

An in situ atlas of mitochondrial DNA in mammalian tissues reveals high content in stem/progenitor cells

The paper creates an in situ atlas of mitochondrial DNA in mammalian tissues, revealing higher mtDNA content in stem/progenitor cells and age-related decreases in renal tubules.

Cell-type specific expression of oncogenic and tumor suppressive microRNAs in the human prostate and prostate cancer

The paper quantifies miRNA expression in prostate stroma and epithelium, finding cell-type specific patterns and associations with prostate cancer recurrence.