Author

B. B. J. Tops

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Assay:organoid / primary culture· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. Janse· 2 shared F. C. P. Holstege· 2 shared H. H. D. Kerstens· 2 shared J. Drost· 2 shared J. H. M. Merks· 2 shared J. J. Molenaar· 2 shared J. Y. Hehir-Kwa· 2 shared M. T. Meister· 2 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

A. Janse

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Author profile →

2 papers

Recent·Most cited

Complex structural variation is prevalent and highly pathogenic in pediatric solid tumors

I. A. E. M. van Belzen, M. C. van Tuil, S. Badloe, A. Janse, E. T. P. Verwiel, M. Santoso, S. de Vos, J. Baker-Hernandez, H. H. D. Kerstens, N. Solleveld-Westerink, M. T. Meister, J. Drost, M. M. van den Heuvel-Eibrink, J. H. M. Merks, J. J. Molenaar, , J. Y. Hehir-Kwa

The paper identifies prevalent and pathogenic complex structural variations in pediatric solid tumors, linking them to adverse clinical outcomes and potential therapeutic targets.

bioRxiv · Sep 19, 2023Cancer Biology

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

M. T. Meister, M. J. A. Groot Koerkamp, T. de Souza, W. B. Breunis, E. Frazer-Mendelewska, M. Brok, J. DeMartino, F. Manders, C. Calandrini, H. H. D. Kerstens, A. Janse, M. E. M. Dolman, S. Eising, K. P. S. Langenberg, M. van Tuil, , F. C. P. Holstege

This study generates tumor organoid models of rhabdomyosarcoma subtypes that closely resemble original tumors and can be used for drug screening and genetic modification.

bioRxiv · Jan 3, 2022Cancer Biology