J. Y. Hehir-Kwa

The paper identifies subclasses of 1q gain in Wilms tumors by integrating genomic and expression data, revealing differences in mutational mechanisms and functional effects.

This study generates tumor organoid models of rhabdomyosarcoma subtypes that closely resemble original tumors and can be used for drug screening and genetic modification.

This study shows that lineage switching in MLL-AF4 leukaemia is driven by dysregulation of epigenetic regulators like NuRD, leading to reprogramming of gene regulatory networks from B lymphoid to myeloid.

This study identifies PPM1D as an oncogene and therapeutic target in neuroblastoma by showing its role in p53 inactivation and tumor growth.