Author

B. Barsi-Rhyne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

M. von Zastrow· 2 shared A. A. Anand· 1 shared A. F. Brilot· 1 shared A. Inoue· 1 shared A. M. Smith· 1 shared A. Manglik· 1 shared A. N. Rizo· 1 shared B. Faust· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

M. von Zastrow

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Author profile →

3 papers

Recent·Most cited

Discrete GPCR-triggered endocytic modes enable β-arrestins to flexibly regulate cell signaling

B. Barsi-Rhyne, A. Manglik, M. von Zastrow

This study identifies two distinct GPCR-triggered endocytic modes in β-arrestins, each with different signaling outcomes and receptor-specific activation.

bioRxiv · Jul 13, 2022Cell Biology

Membrane phosphoinositides stabilize GPCR-arrestin complexes and offer temporal control of complex assembly and dynamics

J. Janetzko, R. Kise, B. Barsi-Rhyne, D. H. Siepe, F. M. Heydenreich, M. Masureel, K. Kawakami, K. C. Garcia, M. Von Zastrow, A. Inoue, B. K. Kobilka

This study identifies membrane phosphoinositides as regulators of GPCR-arrestin complex dynamics, showing they stabilize complexes and enable temporal control of receptor signaling and recycling.

bioRxiv · Oct 9, 2021Biochemistry

An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation

M. Schoof, B. Faust, R. A. Saunders, S. Sangwan, V. V. Rezelj, N. Hoppe, M. Boone, C. Billesboelle, C. Puchades, C. M. Azumaya, H. T. Kratochvil, M. Zimanyi, I. Deshpande, J. Liang, S. Dickinson, , Barile-H

This paper develops a potent synthetic nanobody that neutralizes SARS-CoV-2 by locking its Spike protein in an inactive conformation, enabling aerosol delivery as a prophylactic or therapeutic agent.

bioRxiv · Aug 8, 2020Biochemistry