Author

C. W. McCloskey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

R. Khokha· 4 shared B. Zhang· 2 shared F. Vyas· 2 shared K. Aliar· 2 shared M. Waas· 2 shared P. Tharmapalan· 2 shared T. Kislinger· 2 shared A. B. M. M. K. Islam· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersCancer Biology

R. Khokha

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Metabolic shift to serine pathway induced by lipids confers oncogenic properties in non-transformed breast cells

M. B. Eduardo, G. Cottone, C. W. McCloskey, S. Liu, M. P. Zappia, E. V. Benevolenskaya, A. B. M. M. K. Islam, M. V. Frolov, F. R. Palma, P. Gao, J. Setya, H. Gao, X. Xuei, R. Khokha, J. Locasale, , S. E. Clare

The paper shows that lipid metabolism, specifically through OA, shifts metabolic pathways in breast cells, increasing SAM and 2-HG, which contribute to oncogenic properties and epigenetic changes.

bioRxiv · Feb 21, 2024 · PreprintCancer Biology

FABP7 Progenitors are a Targetable Metabolic Root in the BRCA1 Breast

C. W. McCloskey, B. Zhang, M. Waas, G. Abazari, F. Vyas, K. Aliar, P. Tharmapalan, A. Kuttanamkuzhi, S. Narala, J. Cruikshank, S. O. P. Hofer, H. W. Jackson, T. Kislinger, H. K. Berman, R. Khokha

This study identifies FABP7 progenitors as a targetable metabolic root in BRCA1 breast cancer, showing their dysregulation and potential inhibition via fatty acid metabolism disruption.

bioRxiv · Nov 2, 2023 · PreprintCell Biology

Droplet based low input proteomic platform for rare cell populations

M. Waas, A. Khoo, P. Tharmapalan, C. W. McCloskey, M. Govindarajan, B. Zhang, S. Khan, P. Waterhouse, R. Khokha, T. Kislinger

DROPPS enables high-fidelity proteomic profiling of rare cell populations with low input, revealing CD36 as a marker of progenitor capacity in mammary basal cells.

bioRxiv · Sep 11, 2023 · PreprintBiochemistry

Spatially confined sub-tumor microenvironments orchestrate pancreatic cancer pathobiology

B. T. Grünwald, A. Devisme, G. Andrieux, F. Vyas, K. Aliar, C. W. McCloskey, A. Macklin, G. H. Jang, R. Denroche, J. M. Romero, P. Bavi, P. Bronsert, F. Notta, G. O'Kane, J. Wilson, , R. Khokha

This study identifies spatially confined sub-tumor microenvironments in PDAC that drive distinct tumor progression outcomes.

bioRxiv · Feb 18, 2021Cancer Biology

Transcriptional heterogeneity of stemness phenotypes in the ovarian epithelium

L. E. Carter, D. P. Cook, C. W. McCloskey, T. Dang, O. Collins, L. F. Gamwell, H. A. Dempster, B. C. Vanderhyden

This study investigates stemness traits in ovarian surface epithelium and finds that stemness is context-specific and not consistently linked to specific signaling pathways or a single population.

bioRxiv · Jun 10, 2020Cell Biology