A High-Throughput Screen of a Library of Therapeutics Identifies Substrates of P-glycoprotein
T. D. Lee, O. W. Lee, K. R. Brimacombe, L. Chen, R. Guha, S. Lusvarghi, B. G. Tebase, C. Klumpp-Thomas, R. W. Robey, S. V. Ambudkar, M. Shen, M. M. Gottesman, M. D. Hall
This paper identifies 90 P-gp substrates from 10,804 compounds using a high-throughput screen, including 55 new substrates confirmed by orthogonal assays.
bioRxiv · Jan 23, 2019Pharmacology & Toxicology