Author

S. V. Ambudkar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:zebrafish· 1

Frequent Co-Authors

M. M. Gottesman· 4 shared R. W. Robey· 3 shared L. M. Huff· 2 shared M. D. Hall· 2 shared M. Shen· 2 shared O. W. Lee· 2 shared P. Salazar· 2 shared S. Lusvarghi· 2 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersPharmacology & Toxicology

M. M. Gottesman

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Author profile →

4 papers

Recent·Most cited

The Multidrug Resistance Transporter P-glycoprotein Confers Resistance to Ferroptosis Inducers

W. J. E. Frye, L. M. Huff, J. M. G. Dalmasy, P. Salazar, R. M. Carter, R. T. Gensler, D. Esposito, R. W. Robey, S. V. Ambudkar, M. M. Gottesman

This study shows that P-glycoprotein (P-gp) and ABCG2 confer resistance to ferroptosis inducers, and some inducers inhibit these transporters, suggesting potential drug-drug interactions.

bioRxiv · Feb 23, 2023Pharmacology & Toxicology

Identification of two novel heterodimeric ABC transporters in melanoma: ABCB5β/B6 and ABCB5β/B9

L. Gerard, L. Duvivier, M. Fourrez, P. Salazar, L. Sprimont, D. Xia, S. V. Ambudkar, M. M. Gottesman, J.-P. Gillet

This study identifies two novel heterodimers of ABCB5{beta} in melanoma using bioluminescence resonance energy transfer, co-immunoprecipitation, and proximity ligation assay.

bioRxiv · Oct 21, 2022Biochemistry

Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter

R. W. Robey, A. N. Robinson, F. Ali-Rahmani, L. M. Huff, S. Lusvarghi, S. Vahedi, J. M. Hotz, A. C. Warner, D. Butcher, J. Matta, E. F. Edmondson, T. D. Lee, J. S. Roth, O. W. Lee, M. Shen, , M. M. Gottesman

This study characterizes zebrafish homologs of the human ABCB1 gene, showing that abcb4 closely resembles P-gp in function and localization, while abcb5 differs.

bioRxiv · Feb 18, 2021Pharmacology & Toxicology

A High-Throughput Screen of a Library of Therapeutics Identifies Substrates of P-glycoprotein

T. D. Lee, O. W. Lee, K. R. Brimacombe, L. Chen, R. Guha, S. Lusvarghi, B. G. Tebase, C. Klumpp-Thomas, R. W. Robey, S. V. Ambudkar, M. Shen, M. M. Gottesman, M. D. Hall

This paper identifies 90 P-gp substrates from 10,804 compounds using a high-throughput screen, including 55 new substrates confirmed by orthogonal assays.

bioRxiv · Jan 23, 2019Pharmacology & Toxicology