Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
K. M. Flickinger, K. M. Wilson, N. J. Rossiter, A. L. Hunger, T. D. Lee, M. D. Hall, J. R. Cantor
This study uses conditional lethality profiling in human plasma-like medium to identify drug mechanisms and interactions with nutrients, revealing new therapeutic strategies.
bioRxiv · Jun 4, 2023Cancer Biology
A. Mavropoulos, C. Johnson, V. Lu, J. Nieto, E. Schneider, K. Saini, M. L. Phelan, L. Hsie, M. Wang, J. Cruz, J. Mei, J. Kim, Z. Lian, N. Li, S. C. Boutet, , J. Rao
This study uses deep learning and microfluidic sorting to enrich malignant cells from body fluids, improving detection of tumor fractions and mutations.
bioRxiv · Jan 24, 2023Pathology
R. W. Robey, A. N. Robinson, F. Ali-Rahmani, L. M. Huff, S. Lusvarghi, S. Vahedi, J. M. Hotz, A. C. Warner, D. Butcher, J. Matta, E. F. Edmondson, T. D. Lee, J. S. Roth, O. W. Lee, M. Shen, , M. M. Gottesman
This study characterizes zebrafish homologs of the human ABCB1 gene, showing that abcb4 closely resembles P-gp in function and localization, while abcb5 differs.
bioRxiv · Feb 18, 2021Pharmacology & Toxicology
J. S. Roth, T. D. Lee, D. M. Cheff, M. L. Gosztyla, R. Asawa, C. Danchik, S. Michael, A. Simeonov, C. Klumpp-Thomas, K. Wilson, M. D. Hall
The paper describes NCATS's implementation of mycoplasma and STR testing to improve cell line quality, reducing contamination and misidentification in translational research.
bioRxiv · Oct 9, 2019Cell Biology
O. W. Lee, S. M. Austin, M. R. Gamma, D. M. Cheff, T. D. Lee, K. M. Wilson, J. M. Johnson, J. C. Travers, J. C. Braisted, R. Guha, C. Klumpp-Thomas, M. Shen, M. D. Hall
The paper profiles cytotoxicity of over 100,000 compounds across normal and cancer cell lines to identify cytotoxic compounds and improve screening efficiency.
bioRxiv · Feb 5, 2019Cell Biology
T. D. Lee, O. W. Lee, K. R. Brimacombe, L. Chen, R. Guha, S. Lusvarghi, B. G. Tebase, C. Klumpp-Thomas, R. W. Robey, S. V. Ambudkar, M. Shen, M. M. Gottesman, M. D. Hall
This paper identifies 90 P-gp substrates from 10,804 compounds using a high-throughput screen, including 55 new substrates confirmed by orthogonal assays.
bioRxiv · Jan 23, 2019Pharmacology & Toxicology
J. M. Rohde, K. R. Brimacombe, L. Liu, M. E. Pacold, A. Yasgar, D. M. Cheff, T. D. Lee, G. Rai, B. Baljinnyam, Z. Li, A. Simeonov, M. D. Hall, M. Shen, D. M. Sabatini, M. B. Boxer
The paper develops a biochemical assay to screen for PHGDH inhibitors, identifies piperazine-1-thiourea compounds, and evaluates their biological impact on serine metabolism in cancer cells.
Bioorganic & Medicinal Chemistry · May 1, 2018Peer-reviewedCancer Biology
D. J. Urban, N. J. Martinez, M. I. Davis, K. R. Brimacombe, D. M. Cheff, T. D. Lee, M. J. Henderson, S. A. Titus, R. Pragani, J. M. Rohde, Y. Wang, S. Karavadhi, P. Shah, O. W. Lee, A. Wang, , M. D. Hall
The paper evaluates inhibitors of mutant IDH1 and IDH2 using biochemical and cell-based assays to identify effective compounds for cancer therapy.
bioRxiv · Apr 7, 2017Cancer Biology