M. D. Hall

Pharmaceutical pollution alters the cost of bacterial infection and its relationship to pathogen load

This study shows pharmaceutical pollution alters the virulence and fitness trade-off between hosts and pathogens, even at low concentrations.

Conditional lethality profiling reveals anticancer mechanisms of action and drug-nutrient interactions

This study uses conditional lethality profiling in human plasma-like medium to identify drug mechanisms and interactions with nutrients, revealing new therapeutic strategies.

Is there a sicker sex? Dose relationships modify male-female differences in infection prevalence

The paper investigates how pathogen dose affects male-female differences in infection prevalence, revealing that sex differences in susceptibility are dose-dependent.

Contrasting the form and strength of pre- and postcopulatory sexual selection in a transparent worm with fluorescent sperm

The paper measures pre- and postcopulatory sexual selection in a transparent worm by tracking fluorescent sperm and analyzing morphological traits to identify selection patterns on sperm production and copulatory organ shape.

Anticipating change: the impact of simulated seasonal heterogeneity on heat tolerances along a latitudinal cline.

This study tests how seasonal environmental signals affect thermal tolerance clines in Daphnia carinata clones, finding that latitudinal thermal adaptation remains robust despite seasonal manipulations.

Thermal acclimation to warmer temperatures can protect host populations from both further heat stress and the potential invasion of pathogens

This study investigates how thermal acclimation affects host and pathogen performance in Daphnia magna and Pasteuria ramosa, finding that hosts benefit more from warming than pathogens.

A Suite of TMPRSS2 Assays for Screening Drug Repurposing Candidates as Potential Treatments of COVID-19

The paper develops and validates a series of assays to identify TMPRSS2 inhibitors as potential COVID-19 treatments, identifying six compounds with varying clinical statuses.

Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter

This study characterizes zebrafish homologs of the human ABCB1 gene, showing that abcb4 closely resembles P-gp in function and localization, while abcb5 differs.

Sexually antagonistic evolution of mitochondrial and nuclear linkage

The paper models mito-nuclear linkage evolution, showing it maintains mitochondrial diversity and selects for sex-independent segregation and paternal leakage to mitigate male-harming mtDNA effects.

An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19

The paper describes an enzymatic TMPRSS2 assay for inhibitor discovery and profiling of FDA-approved therapeutics, showing varying potencies of tested compounds.

Targeting ACE2-RBD interaction as a platform for COVID19 therapeutics: Development and drug repurposing screen of an AlphaLISA proximity assay

The paper develops an AlphaLISA assay to measure SARS-CoV-2 spike RBD-ACE2 binding and identifies 25 drug candidates that disrupt this interaction.

Real-time sharing of drug screening data on the NCATS OpenData Portal accelerates translational research

This paper describes the NCATS OpenData Portal, a platform for real-time sharing of drug screening data that accelerates translational research by enabling immediate access to large-scale datasets.

Metabolic scaling has diversified among species, despite an evolutionary constraint within species

The paper shows that metabolic scaling is evolutionarily constrained within species but diversifies across species in cockroaches.

The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators

The paper identifies six autophagy modulators that block SARS-CoV-2 cytopathic effects in Vero-E6 cells with EC50 values between 2.0 and 13 µM.

Travelling with a parasite: the evolution of resistance and dispersal syndrome during experimental range expansion

This study examines how parasite presence during experimental range expansions affects host dispersal syndromes and resistance evolution in Paramecium caudatum.

Keeping it clean: the cell culture quality control experience at the National Center for Advancing Translational Sciences

The paper describes NCATS's implementation of mycoplasma and STR testing to improve cell line quality, reducing contamination and misidentification in translational research.

Identification of activators of human fumarate hydratase by quantitative high-throughput screening

This study identifies small molecule activators of human fumarate hydratase through quantitative high-throughput screening, revealing compounds that enhance FH activity without being substrates or redox agents.

Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening

The paper profiles cytotoxicity of over 100,000 compounds across normal and cancer cell lines to identify cytotoxic compounds and improve screening efficiency.

A High-Throughput Screen of a Library of Therapeutics Identifies Substrates of P-glycoprotein

This paper identifies 90 P-gp substrates from 10,804 compounds using a high-throughput screen, including 55 new substrates confirmed by orthogonal assays.

Spatial control of oxygen delivery to 3D cultures alters cancer cell growth and gene expression

The paper compares cancer cell growth and gene expression in different oxygen environments, finding that controlled oxygen delivery in 3D cultures better mimics physiological conditions.

Anywhere but here: local conditions alone drive dispersal in Daphnia

This study shows Daphnia carinata dispersal is driven by intra-patch conditions, not extra-patch conditions, highlighting partial information use in dispersal decisions.

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

The paper develops a biochemical assay to screen for PHGDH inhibitors, identifies piperazine-1-thiourea compounds, and evaluates their biological impact on serine metabolism in cancer cells.

Assessing Inhibitors Of Mutant Isocitrate Dehydrogenase Using A Suite Of Pre-Clinical Discovery Assays

The paper evaluates inhibitors of mutant IDH1 and IDH2 using biochemical and cell-based assays to identify effective compounds for cancer therapy.