Author

O. W. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Pharmacology & Toxicology· 2 Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 4 Organism:human· 4 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:proteomics· 1 Organism:zebrafish· 1

Frequent Co-Authors

M. D. Hall· 5 shared M. Shen· 5 shared T. D. Lee· 4 shared A. Jadhav· 2 shared C. Klumpp-Thomas· 2 shared D. M. Cheff· 2 shared K. R. Brimacombe· 2 shared M. M. Gottesman· 2 shared

Activity by Year

2017-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersPharmacology & Toxicology

M. D. Hall

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter

R. W. Robey, A. N. Robinson, F. Ali-Rahmani, L. M. Huff, S. Lusvarghi, S. Vahedi, J. M. Hotz, A. C. Warner, D. Butcher, J. Matta, E. F. Edmondson, T. D. Lee, J. S. Roth, O. W. Lee, M. Shen, , M. M. Gottesman

This study characterizes zebrafish homologs of the human ABCB1 gene, showing that abcb4 closely resembles P-gp in function and localization, while abcb5 differs.

bioRxiv · Feb 18, 2021Pharmacology & Toxicology

Identification of activators of human fumarate hydratase by quantitative high-throughput screening

H. Zhu, O. W. Lee, P. Shah, A. Jadhav, X. Xu, S. Patnaik, M. Shen, M. D. Hall

This study identifies small molecule activators of human fumarate hydratase through quantitative high-throughput screening, revealing compounds that enhance FH activity without being substrates or redox agents.

bioRxiv · Jul 2, 2019Biochemistry

Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening

O. W. Lee, S. M. Austin, M. R. Gamma, D. M. Cheff, T. D. Lee, K. M. Wilson, J. M. Johnson, J. C. Travers, J. C. Braisted, R. Guha, C. Klumpp-Thomas, M. Shen, M. D. Hall

The paper profiles cytotoxicity of over 100,000 compounds across normal and cancer cell lines to identify cytotoxic compounds and improve screening efficiency.

bioRxiv · Feb 5, 2019Cell Biology

A High-Throughput Screen of a Library of Therapeutics Identifies Substrates of P-glycoprotein

T. D. Lee, O. W. Lee, K. R. Brimacombe, L. Chen, R. Guha, S. Lusvarghi, B. G. Tebase, C. Klumpp-Thomas, R. W. Robey, S. V. Ambudkar, M. Shen, M. M. Gottesman, M. D. Hall

This paper identifies 90 P-gp substrates from 10,804 compounds using a high-throughput screen, including 55 new substrates confirmed by orthogonal assays.

bioRxiv · Jan 23, 2019Pharmacology & Toxicology

Assessing Inhibitors Of Mutant Isocitrate Dehydrogenase Using A Suite Of Pre-Clinical Discovery Assays

D. J. Urban, N. J. Martinez, M. I. Davis, K. R. Brimacombe, D. M. Cheff, T. D. Lee, M. J. Henderson, S. A. Titus, R. Pragani, J. M. Rohde, Y. Wang, S. Karavadhi, P. Shah, O. W. Lee, A. Wang, , M. D. Hall

The paper evaluates inhibitors of mutant IDH1 and IDH2 using biochemical and cell-based assays to identify effective compounds for cancer therapy.

bioRxiv · Apr 7, 2017Cancer Biology