Author

K. Bhardwaj

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Approach:deep learning· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

B. K. Shoichet· 3 shared A. Basbaum· 2 shared J. M. Braz· 2 shared S. Rodriguez-Rosado· 2 shared Y. Liu· 2 shared A. A. Inoue· 1 shared A. Allikalt· 1 shared A. D. Pandey· 1 shared

Activity by Year

2022-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersPharmacology & Toxicology

B. K. Shoichet

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Rho and a riboswitch regulate mntP expression evading manganese stress and membrane toxicity

A. Prakash, A. Kalita, K. Bhardwaj, R. K. Mishra, D. Ghose, G. Kaur, B. Pani, E. Nudler, D. Dutta

The paper shows Rho terminates transcription at the mntP riboswitch, and manganese activates the riboswitch to restore transcription-translation coupling, preventing membrane toxicity from overexpressed MntP.

bioRxiv · Nov 29, 2023 · PreprintBiochemistry

Structure-Based Discovery of a NPFF1R Antagonist with Analgesic Activity

B. J. Bender, J. E. Pickett, J. Braz, H. J. Kang, S. Gahbauer, K. Bhardwaj, S. Rodriguez-Rosado, Y. Liu, M. Jain, A. Basbaum, B. L. Roth, B. K. Shoichet

This paper identifies a selective NPFF1R antagonist with analgesic properties, showing enhanced pain relief when combined with morphine and reduced side effects.

bioRxiv · Oct 25, 2023 · PreprintPharmacology & Toxicology

Discovery of a functionally selective serotonin 5-HT1A receptor agonist for the treatment of pain

A. Ullrich, J. Schneider, J. M. Braz, E. Neu, N. Staffen, M. Stanek, J. Blahova, T. Hove, T. Albert, A. Allikalt, S. Lober, K. Bhardwaj, S. Rodriguez-Rosado, E. A. Fink, T. Rasmussen, , P. Gmeiner

The paper identifies ST171, a selective 5-HT1A receptor agonist effective in pain models without sedation, and elucidates its mechanism through structural and computational analysis.

bioRxiv · Sep 11, 2023 · PreprintPharmacology & Toxicology

Large library docking for cannabinoid-1 receptor agonists with reduced side effects

T. A. Tummino, C. Iliopoulos-Tsoutsouvas, J. M. Braz, E. S. O'Brien, R. M. Stein, V. Craik, N. K. Tran, S. Ganapathy, F. Liu, Y. Shiimura, F. Tong, T. C. Ho, D. S. Radchenko, Y. S. Moroz, S. R. Rosado, , B. K. Shoichet

The paper identifies a new cannabinoid-1 receptor agonist with reduced side effects through large library docking and experimental validation.

bioRxiv · Feb 27, 2023 · PreprintPharmacology & Toxicology

Insights into the Human Gut Virome by Sampling a Population from the Indian Subcontinent

K. Bhardwaj, A. Garg, A. D. Pandey, H. Sharma, M. kumar, S. Vrati

This study analyzes the gut virome of an Indian population using metagenomics, identifying novel viral families and a core virome composition.

bioRxiv · Jan 20, 2022Microbiology