Enhanced ISGylation reduces respiratory distress following Francisella novicida infection
E. M. Upton, E. K. Luhmann, Y. Zhang, B. M. Ripley, D. K. Meyerholz, L. Radoshevich
This study shows that enhanced ISGylation reduces respiratory distress in Francisella novicida infection by modulating SAMHD1 function, suggesting USP18 inhibition as a therapeutic strategy.
bioRxiv · Sep 19, 2023 · PreprintMicrobiology