Author

L. Radoshevich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Y. Zhang· 4 shared B. M. Ripley· 2 shared B. Manicassamy· 2 shared D. K. Meyerholz· 2 shared E. Luhmann· 2 shared M. Vessely· 2 shared R. Coloma· 2 shared S. Guerra· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

Y. Zhang

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Enhanced ISGylation reduces respiratory distress following Francisella novicida infection

E. M. Upton, E. K. Luhmann, Y. Zhang, B. M. Ripley, D. K. Meyerholz, L. Radoshevich

This study shows that enhanced ISGylation reduces respiratory distress in Francisella novicida infection by modulating SAMHD1 function, suggesting USP18 inhibition as a therapeutic strategy.

bioRxiv · Sep 19, 2023 · PreprintMicrobiology

ISG15-modification of the Arp2/3 complex restricts pathogen spread

Y. Zhang, B. M. Ripley, W. Ouyang, M. Sturtz, E. Upton, E. Luhmann, M. Vessely, R. Coloma, N. Schwery, S. M. Anthony, A. Goeken, T. O. Moninger, J. T. Harty, A. J. Klingelhutz, E. Lundberg, , L. Radoshevich

This study shows ISG15 modifies the Arp2/3 complex to restrict pathogen spread by slowing actin filament formation and stabilizing structures, but pathogens like Listeria exploit dysregulated ISGylation to enhance spread.

bioRxiv · Dec 27, 2022 · PreprintCell Biology

ISG15 is required for the dissemination of Vaccinia virus extracellular virions

M. Becares, M. Albert, C. Tarrega, R. Coloma, M. Falqui, E. Luhmann, L. Radoshevich, S. Guerra

This paper shows that ISG15 regulates Vaccinia virus dissemination by affecting extracellular virion production and actin tail formation.

bioRxiv · Oct 27, 2022 · PreprintImmunology

Ring Finger Protein 213 Assembles into a Sensor for ISGylated Proteins with Antimicrobial Activity

F. Thery, L. Martina, C. Asselman, H. Repo, Y. Zhang, K. Sedeyn, G. D. Moschonas, C. Bredow, Q. W. Teo, J. Zhang, M. Vessely, K. Leandro, D. Eggermont, D. De Sutter, K. Boucher, , F. Impens

This study identifies RNF213 as an ISG15-interacting sensor that detects ISGylated proteins and exhibits broad antimicrobial activity against multiple pathogens.

bioRxiv · Jun 3, 2021Cell Biology

Host Factor Rab11a is Critical for Efficient Assembly of Influenza A Virus Genomic Segments

J. Han, K. Ganti, V. K. Sali, C. Twigg, Y. Zhang, S. Manivasagam, C.-Y. Liang, O. A. Vogel, I. Huang, S. N. Emmanuel, J. Plung, L. Radoshevich, J. T. Perez, A. C. Lowen, B. Manicassamy

This study identifies Rab11a as a critical host factor for influenza A virus genome assembly by facilitating vRNP congregation and specific interactions.

bioRxiv · Apr 6, 2021Microbiology