Author

M. E. Merritt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. R. Malloy· 2 shared E. S. Jin· 2 shared B. N. Newby· 1 shared C. E. Mathews· 1 shared C. E. Shannon· 1 shared C. Yang· 1 shared D. Do· 1 shared D. J. Bezwada· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

C. R. Malloy

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples

F. Cai, D. J. Bezwada, L. Cai, R. Mahar, Z. Wu, P. Pachnis, C. Yang, S. Kelekar, W. Gu, H. S. Vu, T. P. Mathews, L. G. Zacharias, M. Martin-Sandoval, D. Do, K. C. Oaxaca, , R. J. DeBerardinis

This paper develops an MS method to analyze all 16 aspartate and 32 glutamate isotopomers with high sensitivity, enabling pathway discrimination and metabolic heterogeneity studies in human tumors.

bioRxiv · Jul 31, 2022Biochemistry

Human CD8+ T-cells Require Glycolysis to Elicit Effector Function

S. E. Stimpson, J. Chen, B. N. Newby, R. Khattri, H. D. Chapman, T. E. Angelini, M. E. Merritt, D. V. Serreze, C. E. Mathews

This study shows glycolysis is essential for CD8+ T-cell effector function, while mitochondrial respiration is not, and inhibiting glycolysis reduces autoimmunity in a diabetes model.

bioRxiv · Feb 5, 2020 · PreprintImmunology

Hepatic Mitochondrial Remodeling is Mechanistically Linked to Insulin Resistance in Nonalcoholic Fatty Liver Disease

C. E. Shannon, M. Ragavan, J. P. Palavicini, M. Fourcaudot, T. Bakewell, E. S. Jin, C. R. Malloy, X. Han, M. E. Merritt, L. Norton

This study links insulin resistance and mitochondrial remodeling in NAFLD, showing that insulin sensitization improves mitochondrial function without reducing lipid content.

bioRxiv · Jan 2, 2020Biochemistry