Author

B. O'Rourke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Bioengineering· 1 Biophysics· 1 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1

Frequent Co-Authors

D. Ashok· 3 shared A. Cap· 1 shared A. Pekosz· 1 shared A. Sidor· 1 shared A. Tilles· 1 shared B. Dunkerly-Eyring· 1 shared B. Kim· 1 shared B. Parekkadan· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersPathology

D. Ashok

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Innate Immune Activation and Mitochondrial ROS Invoke Persistent Cardiac Conduction System Dysfunction after COVID-19

D. Ashok, T. Liu, J. Criscione, M. Prakash, B. Kim, J. Chow, M. Craney, K. Papanicolaou, A. Sidor, D. B. Foster, A. Pekosz, J. Villano, D.-H. Kim, B. O'Rourke

This study shows that SARS-CoV-2 infection causes persistent cardiac conduction system dysfunction in hamsters, driven by innate immune activation and mitochondrial ROS, with potential implications for long COVID.

bioRxiv · Jan 5, 2024Pathology

Cardiac sympathetic denervation prevents sudden cardiac arrest and improves cardiac function by enhancing mitochondrial-antioxidant capacity

S. Dey, P. Joshi, B. O'Rourke, S. Estes, D. DeMazumder

This study investigates how cardiac sympathetic denervation prevents sudden cardiac arrest and improves cardiac function by enhancing mitochondrial-antioxidant capacity in a pressure-overload heart failure model.

bioRxiv · Jan 29, 2023 · PreprintPhysiology

PDE9 Inhibition Activates PPARa to Stimulate Mitochondrial Fat Metabolism and Reduce Cardiometabolic Syndrome

S. Mishra, V. Hahn, N. Sadagopan, B. Dunkerly-Eyring, S. Rodriguez, D. C. Sarver, R. P. Ceddia, S. Murphy, H. Knutsdottir, V. Jani, D. Ashok, C. U. Oeing, B. O'Rourke, K. Sharma, J. Gangoiti, , D. A. Kass

This study shows PDE9 inhibition activates PPARa to enhance mitochondrial fat metabolism and reduce cardiometabolic syndrome in mice, with potential for treating obesity in men and postmenopausal women.

bioRxiv · Feb 2, 2021 · PreprintPhysiology

Mesenchymal Stromal Cell Delivery via an Ex Vivo Bioreactor Preclinical Test System Attenuates Clot Formation for Intravascular Application

B. O'Rourke, S. Nguyen, A. Tilles, J. Bynum, A. Cap, B. Parekkadan, R. Barcia

This study shows that using a bioreactor to isolate mesenchymal stromal cells (MSCs) delays clot formation compared to free MSCs, suggesting improved safety for systemic administration.

bioRxiv · Nov 20, 2020Bioengineering

MitoWave: Spatiotemporal analysis of mitochondrial membrane potential fluctuations during ischemia-reperfusion

B. O'Rourke, D. Ashok

This paper introduces MitoWave, a tool to analyze mitochondrial membrane potential fluctuations during ischemia-reperfusion, showing significant differences in oscillatory behavior and correlations between frequency and cluster area.

bioRxiv · May 21, 2020 · PreprintCell Biology

Precisely control mitochondria with light to manipulate cell fate decision

P. Ernst, N. Xu, J. Qu, H. Chen, M. S. Goldberg, J. Zhang, B. O'Rourke, X. Liu, L. Zhou

This paper develops an optogenetic method to control mitochondrial membrane potential and shows its effects on cell fate, finding that light-induced depolarization can induce apoptosis or cytoprotection depending on duration and intensity.

bioRxiv · Nov 13, 2018Biophysics