R. P. Ceddia

Discovery of another mechanism for the inhibition of particulate guanylyl cyclases by the natriuretic peptide clearance receptor

This paper identifies a new mechanism by which NPRC inhibits NP signaling by forming heterodimers with NPRA or NPRB, preventing cGMP production.

Glucagon-Like Peptide-1 Receptor Activation Stimulates PKA-Mediated Phosphorylation of Raptor and this Contributes to the Weight Loss Effects of Liraglutide

This study shows that GLP-1R agonist liraglutide induces PKA-mediated phosphorylation of Raptor at Ser791, which contributes to its weight loss effect.

PDE9 Inhibition Activates PPARa to Stimulate Mitochondrial Fat Metabolism and Reduce Cardiometabolic Syndrome

This study shows PDE9 inhibition activates PPARa to enhance mitochondrial fat metabolism and reduce cardiometabolic syndrome in mice, with potential for treating obesity in men and postmenopausal women.

Increased energy expenditure and protection from diet-induced obesity in mice lacking the cGMP-specific phosphodiesterase, PDE9

This study shows that mice lacking PDE9 are resistant to obesity and have increased energy expenditure on a high-fat diet, with improved glucose handling and reduced hepatic steatosis.

Removing the Gβγ-SNAP25 brake on exocytosis enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity

This paper shows that disrupting the Gβγ-SNAP25 interaction improves insulin action, promotes adipocyte browning, and protects against diet-induced obesity in mice.