Author

E. E. Giorgi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 2 Evolutionary Biology· 1

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Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Approach:statistical model· 5 Organism:rat· 4 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:benchmarking· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

F. Gao· 3 shared A. Kumar· 2 shared B. F. Haynes· 2 shared B. Foley· 2 shared B. Korber· 2 shared D. C. Montefiori· 2 shared E. Lindemuth· 2 shared F. Bibollet-Ruche· 2 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

F. Gao

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

A novel HIV triple broadly neutralizing antibody (bNAb) combination-based passive immunization of infant rhesus macaques achieves durable protective plasma neutralization levels and mediates anti-viral effector functions.

S. Dankwa, C. Kosman, M. Dennis, E. E. Giorgi, K. Vuong, I. Pahountis, A. Garza, J. McCarthy, B. T. Mayer, J. T. Ngo, C. A. Enemuo, D. G. Carnathan, S. Stanfield-Oakley, S. J. Berendam, C. Weinbaum, , R. Goswami

This study evaluates a triple bNAb combination in infant rhesus macaques, showing durable neutralization and effector functions with high predicted prevention efficacy against HIV strains.

PLOS ONE · Nov 11, 2024Peer-reviewedImmunology

A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies

F. Bibollet-Ruche, R. M. Russell, W. Ding, W. Liu, Y. Li, K. Wagh, D. Wrapp, R. Habib, A. N. Skelly, R. S. Roark, S. Sherrill-Mix, S. Wang, J. Rando, E. Lindemuth, K. Cruickshank, , B. H. Hahn

This study identifies a new class of V2-directed cross-neutralizing antibodies targeting a cryptic epitope in occluded-open HIV and SIV Env trimers.

bioRxiv · Oct 18, 2022Immunology

Different evolutionary pathways of HIV-1 between fetus and mother perinatal transmission pairs indicate unique immune selection pressure in fetuses

M. H. Marichannegowda, M. Mengual, A. Kumar, E. E. Giorgi, J. Tu, D. Martinez, X. Li, L. Feng, S. Permar, F. Gao

This study analyzes HIV-1 env gene evolution in 12 perinatal transmission pairs, finding that most infections occur within two months of birth and fetal viruses show unique selection pressures.

bioRxiv · Aug 28, 2020Microbiology

Recapitulation of HIV-1 Env-Antibody Coevolution in Macaques Leading to Neutralization Breadth

R. S. Roark, H. Li, W. B. Williams, H. Chug, R. D. Mason, J. Gorman, S. Wang, F.-H. Lee, J. Rando, M. Bonsignori, K.-K. Hwang, K. O. Saunders, K. Wiehe, M. A. Moody, P. T. Hraber, , C. A Schramm

Virus-antibody coevolution in rhesus macaques recapitulates developmental features of human antibodies.

bioRxiv · Aug 5, 2020Immunology

Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2

B. Korber, W. Fischer, S. G. Gnanakaran, H. Yoon, J. Theiler, W. Abfalterer, B. Foley, E. E. Giorgi, T. Bhattacharya, M. D. Parker, D. G. Partridge, C. M. Evans, T. de Silva, C. C. LaBranche, D. C. Montefiori, Sheffield COVID-19 Genomics Group

The paper develops a pipeline to track SARS-CoV-2 mutations in the Spike protein, identifying D614G as a rapidly spreading mutation with potential implications for transmission and immune evasion.

bioRxiv · Apr 29, 2020Evolutionary Biology

Emergence of SARS-CoV-2 through Recombination and Strong Purifying Selection

X. Li, E. E. Giorgi, M. H. Marichann, B. Foley, C. Xiao, X.-p. Kong, Y. Chen, B. Korber, F. Gao

The paper identifies recombination and purifying selection in coronaviruses from different hosts as key factors in SARS-CoV-2 emergence.

bioRxiv · Mar 20, 2020Microbiology

Maternal alum-adjuvanted recombinant HIV Env vaccine does not enhance autologous virus neutralization in HIV-infected pregnant women

E. D. Hompe, J. F. Mangold, J. A. Eudailey, E. E. Giorgi, A. Kumar, E. McGuire, B. F. Haynes, M. A. Moody, P. F. Wright, G. G. Fouda, F. Gao, S. R. Permar

This study evaluates whether maternal HIV Env vaccination boosts autologous virus neutralization in HIV-infected pregnant women, finding no significant enhancement in neutralization potency.

bioRxiv · Dec 11, 2019 · PreprintImmunology