J. T. Ngo

A novel HIV triple broadly neutralizing antibody (bNAb) combination-based passive immunization of infant rhesus macaques achieves durable protective plasma neutralization levels and mediates anti-viral effector functions.

This study evaluates a triple bNAb combination in infant rhesus macaques, showing durable neutralization and effector functions with high predicted prevention efficacy against HIV strains.

Fe-TAMLs as a new class of small molecule peroxidase probes for correlated light and electron microscopy

The paper introduces Fe-TAML, a small molecule peroxidase probe for correlated light and electron microscopy, demonstrating its use in imaging DNA, tagged proteins, and endogenous proteins.

Focusing antibody responses to the fusion peptide in rhesusmacaques

This study uses continuous immunogen delivery in rhesus macaques to focus antibody responses on the HIV fusion peptide, identifying key residues for vaccine design.

A Genetically Encodable and Chemically Disruptable System for Synthetic Post-Translational Modification Dependent SynNotch Signaling

This paper introduces a system for controlling synthetic signaling proteins through post-translational modifications using genetically encodable and chemically disruptable components.

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

The paper uses cryoEM to analyze polyclonal antibody responses to HIV Env immunogens in rhesus macaques, revealing structural differences in antibody binding and immunogenicity of engineered mutations and glycan sites.

Split-miniSOG for detecting and localizing intracellular protein-protein interactions: application to correlated light and electron microscopy

The paper introduces Split-miniSOG, a PCA method to detect and localize PPIs using correlated light and electron microscopy.