The E3 ligase HECTD4 regulates COX-2 dependent tumor progression and metastasis
Joanna A. Vuille, Cem Tanrıöver, Ezgi Antmen, Douglas Scott Micalizzi, Richard Y. Ebright, Sambhavi Animesh, Robert Tyler Morris, Soroush Hajizadeh, Zachary J. Nicholson, Hunter C. Russell, Eric F. Zaniewski, Ben S. Wittner, Ben K. Wesley, Ji Eun Kwak, Julian Grünewald, , Daniel A. Haber
The paper identifies HECTD4 as a tumor and metastasis suppressor that targets COX-2 for degradation, with COX-2 stabilization driving pro-tumorigenic effects in breast cancer.
Proceedings of the National Academy of Sciences · Aug 6, 2025Peer-reviewedCancer Biology