Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death
Michael A. Margreiter, Monika Witzenberger, Yasmine Wasser, Elena Davydova, Robert Janowski, Jonas Metz, Pardes Habib, Sabri E. M. Sahnoun, Carina Sobisch, Benedetta Poma, Oscar Palomino‐Hernández, Mirko Wagner, Thomas Carell, Nadim Jon Shah, Jörg Bernhard Schulz, , Giulia Rossetti
The paper identifies and validates small-molecule inhibitors of TRMT2A that reduce polyQ aggregation and cell death in human cells.
Computational and Structural Biotechnology Journal · Dec 28, 2021Peer-reviewedMolecular Biology