Delivery of caspase inhibitors through GSDMD pores to inhibit pyroptosis
Katarzyna M. Groborz, Melissa E. Truong, Irma B. Stowe, Bettina L. Lee, Robert S. Jones, Emile G. Plise, Elizabeth S. Levy, Ponien Kou, Wyne P. Lee, Juan Zhang, Julia Nguyen, Małgorzata Kalinka, Marcin Drąg, Nobuhiko Kayagaki, Kim Newton, , Vishva M. Dixit
This study develops covalent caspase inhibitors that block pyroptosis and IL-1β secretion through GSDMD pores, showing therapeutic potential for inflammatory diseases.
bioRxiv · Feb 11, 2025 · PreprintCell Biology