The paper shows IRF2 degradation by IRF1 during immune responses enhances ISG transcription, revealing a regulatory circuit between IRF1 and IRF2 in innate immunity.

bioRxiv · Sep 23, 2025 · PreprintImmunology

Delivery of caspase inhibitors through GSDMD pores to inhibit pyroptosis

Katarzyna M. Groborz, Melissa E. Truong, Irma B. Stowe, Bettina L. Lee, Robert S. Jones, Emile G. Plise, Elizabeth S. Levy, Ponien Kou, Wyne P. Lee, Juan Zhang, Julia Nguyen, Małgorzata Kalinka, Marcin Drąg, Nobuhiko Kayagaki, Kim Newton, , Vishva M. Dixit

This study develops covalent caspase inhibitors that block pyroptosis and IL-1β secretion through GSDMD pores, showing therapeutic potential for inflammatory diseases.

bioRxiv · Feb 11, 2025 · PreprintCell Biology

The Gag Protein PEG10 Binds to RNA and Regulates Trophoblast Stem Cell Lineage Specification.

Mona Abed, Erik Verschueren, Hanna G. Budayeva, Peter Jianrui Liu, Donald S. Kirkpatrick, Rohit Reja, Sarah Kummerfeld, Joshua D. Webster, Sarah Gierke, Mike Reichelt, Keith R. Anderson, Robert J. Newman, Merone Roose‐Girma, Zora D. Modrusan, Hazal Pektas, , Vishva M. Dixit

This study shows that PEG10 binds RNA and regulates trophoblast stem cell differentiation into placental lineages by stabilizing key RNAs like Hbegf.

PLoS ONE · Apr 5, 2019Peer-reviewedMolecular Biology