Nobuhiko Kayagaki

This study identifies NINJ1 as a mediator of hepatic ischemia-reperfusion injury, showing its role in cell death and inflammation, and suggests it as a therapeutic target.

The paper shows IRF2 degradation by IRF1 during immune responses enhances ISG transcription, revealing a regulatory circuit between IRF1 and IRF2 in innate immunity.

This study develops covalent caspase inhibitors that block pyroptosis and IL-1β secretion through GSDMD pores, showing therapeutic potential for inflammatory diseases.

PerturbView enables highly multiplexed optical pooled screens in primary cells and tissues by improving barcode amplification, revealing regulators of NFκB signaling and enabling spatial transcriptomics integration.