Author

Irma B. Stowe

Genentech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Nobuhiko KayagakiiD· 2 shared Ali MirzaesmaeiliiD· 1 shared Allen Volchuk· 1 shared B. MartinsiD· 1 shared Benjamin Ethan SteinbergiD· 1 shared Bettina L. Lee· 1 shared Blayne Amir SayediD· 1 shared Claire J. Hur· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Nobuhiko KayagakiORCID

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2 papers

Recent·Most cited

NINJ1 mediates hepatic ischemia-reperfusion injury

Jan Mossemann, B. Martins, Y. Zhao, Fiorelle Aguilar, Daria Taskina, Claire J. Hur, Allen Volchuk, Gang Ye, Danish Ali, Ali Mirzaesmaeili, Iram Fatima S. Siddiqui, Ghazal Goodarzi, Philip J. Bilan, Irma B. Stowe, Nobuhiko Kayagaki, , Blayne Amir Sayed

This study identifies NINJ1 as a mediator of hepatic ischemia-reperfusion injury, showing its role in cell death and inflammation, and suggests it as a therapeutic target.

bioRxiv · Feb 10, 2026 · PreprintImmunology

Delivery of caspase inhibitors through GSDMD pores to inhibit pyroptosis

Katarzyna M. Groborz, Melissa E. Truong, Irma B. Stowe, Bettina L. Lee, Robert S. Jones, Emile G. Plise, Elizabeth S. Levy, Ponien Kou, Wyne P. Lee, Juan Zhang, Julia Nguyen, Małgorzata Kalinka, Marcin Drąg, Nobuhiko Kayagaki, Kim Newton, , Vishva M. Dixit

This study develops covalent caspase inhibitors that block pyroptosis and IL-1β secretion through GSDMD pores, showing therapeutic potential for inflammatory diseases.

bioRxiv · Feb 11, 2025 · PreprintCell Biology