Sang Yong Kim

This study identifies DeSI1 as a cyclin D-CDK4/6 substrate whose phosphorylation regulates membrane and mitochondrial protein supply during proliferation.

The paper genomically rewrote a mouse Taf1 allele with a human XDP patient-derived TAF1 allele, revealing that intronic SVA retrotransposons reduce TAF1 levels and cause neurodegeneration.

The paper identifies zinc finger proteins that establish distinct chromatin boundaries at Hox clusters during development, working with cohesin to regulate cell fate.

This paper introduces mSwAP-In, a method for efficient genome rewriting in mouse embryonic stem cells, demonstrating its use for Trp53 and ACE2 locus modifications to create more accurate disease models.

This study demonstrates that a circular human artificial chromosome can be transmitted through three generations of mice without health or reproductive issues.

This study identifies Klf5 as a key regulator of bi-potential cell fate in mouse preimplantation embryos by controlling both ICM and TE specification genes.

This study shows that reducing EHMT1/2 activity during reprogramming with ascorbic acid impairs iPSC formation and viability, highlighting the role of H3K9 methylation in reprogramming efficiency.