Author

Biyun Xue

University of Iowa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Stanley M. PerlmaniD· 3 shared Alejandro A. PezzuloiD· 2 shared Andrew L. ThurmaniD· 2 shared Christine Wohlford-Lenane· 2 shared David Kyle MeyerholziD· 2 shared Jian Hua ZhengiD· 2 shared Paul B. McCrayiD· 2 shared Shreya GhimireiD· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersCell Biology

Stanley M. PerlmanORCID

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Author profile →

3 papers

Recent·Most cited

IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo

Shreya Ghimire, Biyun Xue, Kun Li, Ryan M. Gannon, Christine Wohlford-Lenane, Andrew L. Thurman, Huiyu Gong, Grace C. Necker, Jian Hua Zheng, David Kyle Meyerholz, Stanley M. Perlman, Paul B. McCray, Alejandro A. Pezzulo

This study shows IL-13 protects airway epithelial cells from SARS-CoV-2 infection in vitro but worsens disease severity in mice through eicosanoid signaling.

EBioMedicine · Sep 17, 2025Peer-reviewedCell Biology

A predominately pulmonary activation of complement in a mouse model of severe COVID-19

Peter J. Szachowicz, Christine Wohlford-Lenane, Cobey J. H. Donelson, Shreya Ghimire, Andrew L. Thurman, Biyun Xue, Timothy J. Boly, Abhishek Verma, Leila MašinoviĆ, Jennifer Bermick, Tayyab Rehman, Stanley M. Perlman, David Kyle Meyerholz, Alejandro A. Pezzulo, Yuzhou Zhang, , Paul B. McCray

This study identifies pulmonary complement activation in a mouse model of severe COVID-19, showing local complement production and its role in lung injury.

iScience · Feb 1, 2025Peer-reviewedImmunology

SARS-CoV-2 infection unevenly impacts metabolism in the coronal periphery of the lungs

Jarrod A. Laro, Biyun Xue, Jian Hua Zheng, Monica Ness, Stanley M. Perlman, Laura‐Isobel McCall

This study shows SARS-CoV-2 infection causes greater metabolic disturbance in peripheral lung tissue than central tissue, despite higher viral loads in the center.

iScience · Jan 2, 2025Peer-reviewedMicrobiology