Monoclonal nephritic factors reveal insights into C3 convertase dynamics and dysregulation
Seth J. Welsh, Christopher T. Culek, Zhen Xu, Héctor Martín Merinero, Jannik Sichau, William D. Walls, Renee X. Goodfellow, Dingwu Shao, Cobey J. H. Donelson, Kameron Kruger, Sarah Roberts, Nicole C. Meyer, Angela F.M. Nelson, Anna R Carmen, Sydney S. Jellison, , Richard J. Smith
The paper identifies monoclonal C3- and C5-nephritic factors, reveals their structural interactions with convertases, and explains their dual role in activating or inhibiting convertase activity.
bioRxiv · Jun 12, 2026 · PreprintImmunology